Relations of advanced glycation endproducts and dicarbonyls with endothelial dysfunction and low-grade inflammation in individuals with end-stage renal disease in the transition to renal replacement therapy: A cross-sectional observational study.
Remy J H MartensNatascha J H BroersBernard CanaudMaarten H L ChristiaansTom CornelisAdelheid GaulyMarc M H HermansConstantijn J A M KoningsFrank M van der SandeJean L J M ScheijenFrank StifftJoris J J M WirtzJeroen P KoomanCasper G SchalkwijkPublished in: PloS one (2019)
In individuals with CKD5-ND, higher levels of serum AGEs and serum dicarbonyls were related to biomarkers of ED and LGI after adjustment for age, sex and diabetes mellitus. Correlations were attenuated by eGFR, suggesting that eGFR confounds and/or mediates the relation of serum AGEs and dicarbonyls with ED and LGI.