Identification of the skeletal progenitor cells forming osteophytes in osteoarthritis.
Anke J RoelofsKarolina KaniaAlexandra J RafipayMeike SambaleStephanie T KuwaharaFraser L CollinsJoanna SmeetonMaxwell A SerowokyLynn RowleyHui WangRené GronewoldChrysa KapeniSimón Méndez-FerrerChristopher B LittleJohn F BatemanThomas PapFrancesca V MarianiJoanna SherwoodJ Gage CrumpCosimo De BariPublished in: Annals of the rheumatic diseases (2020)
Our findings reveal distinct periosteal and synovial skeletal progenitors that cooperate to form osteophytes in OA. These cell populations could be targeted in disease modification for treatment of OA.