Copper-Mediated Aminoquinoline-Directed Radiofluorination of Aromatic C-H Bonds with K18 F.

So Jeong Lee Katarina J Makaravage Allen F Brooks Peter J H Scott Melanie S Sanford

Published in: Angewandte Chemie (International ed. in English) (2019)

A Cu-mediated ortho-C-H radiofluorination of aromatic carboxylic acids that are protected as 8-aminoquinoline benzamides is described. The method uses K18 F and is compatible with a wide range of functional groups. The reaction is showcased in the high specific activity automated synthesis of the RARβ2 agonist [18 F]AC261066.

Keyphrases

amino acid
machine learning
high throughput
aqueous solution