Influence of Different Diagnostic Criteria on Alzheimer Disease Clinical Research.
Andrei BiegerWagner S BrumWyllians V BorelliJoseph TherriaultMarco A De BastianiAmanda G MoreiraAndréa L BenedetJoão Pedro Ferrari-SouzaJaderson C Da CostaDiogo O SouzaRaphael Machado do CastilhosArtur Francisco Schumacher SchuhMarcia L Fagundes ChavesMichael SchöllHenrik ZetterbergKaj BlennowTharick Ali PascoalSerge GauthierPedro Rosa-NetoLucas P SchillingEduardo R Zimmernull nullPublished in: Neurology (2024)
Over 42% of the studied population presented discordant diagnoses when using the different examined AD criteria, mostly in individuals with a single positive biomarker. Except for 2018 NIA-AA, all guidelines identified asymptomatic individuals at risk of cognitive impairment. Our findings highlight important differences between the guidelines, emphasizing the necessity for updated criteria with enhanced staging metrics, considering clinical, research, therapeutic, and trial design aspects.