Analysis of Interactions between Telomeric i-Motif DNA and a Cyclic Tetraoxazole Compound.

Shadi Sedghi Masoud Yudai YamaokiYue MaAdrien MarchandFernaldo Richtia WinnerdyValerie Gabelica Anh-Tuan Phan Masato Katahira Kazuo Nagasawa

Published in: Chembiochem : a European journal of chemical biology (2018)

The interaction of a macrocyclic tetraoxazole compound, L2H2-4OTD (1), with two aminoalkyl side chains and telomeric i-motif, was investigated by means of electrophoretic mobility shift assay, circular dichroism spectroscopy, mass spectrometry and NMR spectroscopy analyses. The results indicate that 1 interacts with the i-motif structure at two preferred binding sites.

Keyphrases

mass spectrometry
single molecule
high resolution
dna damage response
circulating tumor
high throughput
liquid chromatography
atomic force microscopy
binding protein
high performance liquid chromatography
gas chromatography
capillary electrophoresis
solid state
dna damage
nucleic acid