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Salivary gland hyalinizing clear-cell carcinoma with cutaneous metastasis: A rare and deceptive tumor.

Rand Abou ShaarSheeren ZiaMohamed AlhamarTheresa RomanoBrandon ShawChristian KellerBen J Friedman
Published in: Journal of cutaneous pathology (2020)
Clear-cell carcinoma (CCC) is an uncommon malignant tumor of minor salivary glands. It characteristically has a low-grade morphology and a favorable outcome by most reports. An EWSR1-ATF1 fusion can be detected in the majority of cases. We present a rare case of CCC, which had an aggressive course with the development of cutaneous metastases. Practicing dermatopathologists should be aware of this tumor given its low-grade appearance and histopathologic resemblance to other primary cutaneous adnexal and metastatic neoplasms.
Keyphrases
  • low grade
  • high grade
  • rare case
  • small cell lung cancer
  • squamous cell carcinoma
  • transcription factor
  • electronic health record