Chitinase-3-like 1 protein (CHI3L1) locus influences cerebrospinal fluid levels of YKL-40.

Yuetiva K DemingKathleen BlackDavid CarrellYefei CaiJorge L Del-AguilaMaria Victoria FernandezJohn BuddeShengMei MaBenjamin SaefBill HowellsSarah BertelsenKuan-Lin HuangCourtney L SutphenRawan TarawnehAnne M FaganDavid M HoltzmanJohn C MorrisAlison M GoateJoseph D DoughertyCarlos Cruchaga

Published in: BMC neurology (2016)

CSF YKL-40 levels are likely a biomarker for AD, but we found no evidence that they are an AD endophenotype. YKL-40 levels are highly regulated by genetic variation, and by including genetic information the strength of the correlation between YKL-40 and ptau181 levels is significantly improved. Our results suggest that studies of potential biomarkers may benefit from including genetic information.

Keyphrases

cerebrospinal fluid
genome wide
healthcare
copy number
genome wide association study