Whole genome sequencing-based copy number variations reveal novel pathways and targets in Alzheimer's disease.

Chen MingMinghui WangQian WangRyan NeffErming WangQi ShenJoseph S ReddyXue WangMariet AllenNilüfer Ertekin-TanerPhilip L De JagerDavid A BennettVahram HaroutunianEric SchadtBin Zhang

Published in: Alzheimer's & dementia : the journal of the Alzheimer's Association (2021)

We identify CNVs as potential genetic regulators of immune response in AD. The identified CNVs and their downstream gene networks reveal novel pathways and targets for AD.

Keyphrases

copy number
genome wide
mitochondrial dna
immune response
dna methylation
single cell
cognitive decline
dendritic cells
toll like receptor
inflammatory response