The rs1862513 promoter variant of resistin gene influences susceptibility to nonalcoholic fatty liver disease.

Shadi Nouri Mahsa Navari Radmehr Shafiee Touraj Mahmoudi Gholamreza Rezamand Asadollah Asadi Hossein Nobakht Reza Dabiri Hamid Farahani Seidamir Pasha Tabaeian

Published in: Revista da Associacao Medica Brasileira (1992) (2024)

We found for the first time an association between biopsy-proven nonalcoholic fatty liver disease and RETN -420C>G promoter polymorphism. The carriers of the RETN -420C>G "CC" genotype had a 53% decreased risk for nonalcoholic fatty liver disease. Our findings, however, need to be corroborated by further studies.

Keyphrases

dna methylation
liver fibrosis
transcription factor
gene expression
genome wide
copy number
ultrasound guided
fine needle aspiration
genome wide identification