First in Human Evaluation and Dosimetry Calculations for Peptide 124I-p5+14-a Novel Radiotracer for the Detection of Systemic Amyloidosis Using PET/CT Imaging.

Jonathan S WallEmily B MartinAaron EndsleyAlan C StuckeyAngela D WilliamsDustin PowellBryan WhittleSarah HallTyler R LambethRyan R JulianMichael StabinRonald H LandsStephen J Kennel

Published in: Molecular imaging and biology (2021)

Peptide 124I-p5+14 rapidly distributes to anatomic sites consistent with the presence of amyloid in patients with systemic AL. The dosimetry estimates established in this cohort are acceptable for whole-body PET/CT imaging. Pharmacokinetic parameters are heterogeneous and consistent with uptake of the tracer in an amyloid compartment. PET/CT imaging of 124I-p5+14 may facilitate non-invasive detection of amyloid in multiple organ systems.

Keyphrases

pet ct
positron emission tomography
high resolution
endothelial cells
pet imaging
computed tomography
loop mediated isothermal amplification
molecular dynamics
density functional theory