The multi-site docking protein Grb2-associated binder 1 (Gab1) enhances interleukin-6-induced MAPK-pathway activation in an SHP2-, Grb2-, and time-dependent manner.

Hannes BongartzKaren GilleWiebke HessenkemperKatharina MandelMarc LewitzkyStephan M FellerFred Schaper

Published in: Cell communication and signaling : CCS (2019)

Overall, we elaborated the molecular requirements for Gab1-dependent, spatiotemporal orchestration of interleukin-6-dependent MAPK signalling. We discriminated IL-6-induced Gab1-independent, early activation of MAPK signalling and Gab1-dependent, sustained activation of MAPK signalling.

Keyphrases

signaling pathway
oxidative stress
pi k akt
diabetic rats
high glucose
protein protein
molecular dynamics
endothelial cells
molecular dynamics simulations
amino acid