Skeletal muscle atrophy is exacerbated by steatotic and fibrotic liver-derived TNF-alpha in senescence-accelerated mice.

Yohei ShirakamiJunichi KatoToshihide MaedaTakayasu IdetaKenji ImaiHiroyasu SakaiMakoto ShirakiMasahito Shimizu

Published in: Journal of gastroenterology and hepatology (2023)

The findings of this study revealed an aspect of liver-muscle interaction, which might be important in developing treatments for sarcopenia associated with liver diseases.

Keyphrases

skeletal muscle
insulin resistance
rheumatoid arthritis
systemic sclerosis
endothelial cells
idiopathic pulmonary fibrosis
single cell
metabolic syndrome
high fat diet induced
oxidative stress