Differences in Cardiac Troponin T Composition in Myocardial Infarction and End-Stage Renal Disease Patients: A Blood Tube Effect?

Wim H M VroemenEllen J S DenessenWilliam P T M van DoornKelly E J M PelzerTilman M HackengElisabeth J R LitjensYvonne M C HenskensFrank M van der SandeWill K W H WodzigJeroen P KoomanOtto BekersDouwe de BoerAlma M A Mingels

Published in: The journal of applied laboratory medicine (2024)

The extent of cTnT degradation in vitro is dependent on the (anti)coagulation method, without impacting hs-cTnT concentrations. Furthermore, mainly larger cTnT proteoforms were present in MI patients, while in ESRD patients mainly small 15 to 18 kDa cTnT fragments were found. These insights are essential when developing a novel hs-cTnT assay targeting larger cTnT proteoforms.

Keyphrases

end stage renal disease
chronic kidney disease
peritoneal dialysis
ejection fraction
newly diagnosed
prognostic factors
heart failure
high throughput
heat shock protein