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Rewiring the logic board of IFN signaling.

John D MacMicking
Published in: Science signaling (2022)
Interferons (IFNs) activate cell-autonomous immunity to combat infection and control inflammation. In this issue of Science Signaling , Boccuni et al. reveal how macrophages incorporate stress signals through the p38 MAPK pathway to enhance IFN-induced responses against intracellular pathogens.
Keyphrases
  • single cell
  • immune response
  • dendritic cells
  • oxidative stress
  • high glucose
  • cell therapy
  • genome wide
  • drug induced
  • gram negative
  • reactive oxygen species
  • dna methylation
  • stress induced