Serum CD73 is a prognostic factor in patients with metastatic melanoma and is associated with response to anti-PD-1 therapy.

Roberta TurielloMariaelena CaponeDiana GiannarelliElva MorrettaMaria Chiara MontiGabriele MadonnaDomenico MallardoLucia FestinoRosa AzzaroMitchell P LevesqueLaurence ImhofBenjamin WeideTeresa AmaralMarc ChevrierAntje SuckerPiotr RutkowskiDirk SchadendorfCeleste LebbeJason John Luke Kilian Wistuba-HamprechtReinhard DummerAldo PintoSilvana MorelloPaolo A Ascierto

Published in: Journal for immunotherapy of cancer (2021)

Our data indicate the relevance of serum CD73 in patients with advanced melanoma receiving anti-PD-1 therapy and support further investigation on targeting CD73 in combination with anti-PD-1 antibodies.

Keyphrases

prognostic factors
nk cells
stem cells
big data
cancer therapy
machine learning
mesenchymal stem cells
artificial intelligence