Rapid Serial Immunoprofiling of the Tumor Immune Microenvironment by Fine Needle Sampling.

Juhyun OhJonathan C T CarlsonChristian Landeros Hakho LeeScott FergusonWilliam C Faquin Md PhDJohn R ClarkMikael J PittetSara I PaiRalph Weissleder

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2021)

The FAST-FNA is an innovative technology that combines bio-orthogonal chemistry coupled with a computational analysis pipeline for the comprehensive profiling of single cells obtained through FNA. This is the first demonstration that the complex and rapidly evolving TME during treatment can be accurately and serially measured by simple FNA.

Keyphrases

fine needle aspiration
ultrasound guided
induced apoptosis
stem cells
cell cycle arrest
air pollution
single cell
endoplasmic reticulum stress
oxidative stress
signaling pathway
pi k akt