Evaluating Permeability Surface-Area Product as a Measure of Blood-Brain Barrier Permeability in a Murine Model.
Elizabeth K WeidmanC P FoleyOmar N KallasJonathan P DykeAjay GuptaA E GiambroneJana IvanidzeHediyeh BaradaranDouglas J BallonPina C SanelliPublished in: AJNR. American journal of neuroradiology (2016)
Permeability surface-area product is increased in situations with known disruptions of the BBB, as evidenced by immunologic staining of large-vector passage through the BBB and concordance with contrast-enhancement measurements in a murine model. Quantitative permeability surface-area product has potential as an imaging marker of BBB permeability.