Preclinical PET imaging with the novel human antibody 89Zr-DFO-REGN3504 sensitively detects PD-L1 expression in tumors and normal tissues.

Marcus P KellySosina MakonnenCarlos HickeyT Cody ArnoldJason T GiurleoRichard TavaréMakenzie DantonChristian GranadosIshita ChatterjeeDrew DudgeonMarc W RetterDangshe MaWilliam C OlsonGavin ThurstonJessica R Kirshner

Published in: Journal for immunotherapy of cancer (2021)

This work supports the clinical translation of 89Zr-REGN3504 immuno-PET for the assessment of PD-L1 expression. Future clinical studies will aim to investigate the utility of 89Zr-REGN3504 immuno-PET for predicting and monitoring response to anti-PD-1 therapy.

Keyphrases

pet imaging
positron emission tomography
endothelial cells
gene expression
computed tomography
induced pluripotent stem cells
current status
mesenchymal stem cells