Developmental pharmacogenetics of CYP2C19 in neonates and young infants: omeprazole as a probe drug.

Wei ZhaoStéphanie LerouxValérie BiranÉvelyne M Jacqz-Aigrain

Published in: British journal of clinical pharmacology (2018)

Developmental pharmacogenetics of CYP2C19 was quantitatively described in neonates and young infants using omeprazole as a probe drug. Our findings emphasize the importance of semiphysiological developmental pharmacokinetic modelling approach when evaluating developmental pharmacogenetics of drugs with multiple routes of biotransformation.

Keyphrases

quantum dots
low birth weight
living cells
middle aged
drug induced
emergency department
adverse drug
preterm infants
preterm birth