A novel approach for therapeutic drug monitoring of valproic acid using ATR-FTMIR spectroscopy and non-linear support vector regression.

Aimen El Orche Amine Cheikh Joel B Johnson Omar ElhamdaouiSamira JawhariMy El Abbes Faouzi Yahia CherrahMohamed MbarkiMustapha Bouatia

Published in: Journal of AOAC International (2022)

FTIR spectroscopy was evaluated for the first time to predict valproic acid in human plasma for TDM. Two regressions were evaluated to predict valproic acid in human plasma, and the best performing model was obtained using nonlinear support vector regression.

Keyphrases

high resolution
single molecule
solid state
mass spectrometry