Assessment of central vein sign and paramagnetic rim lesions in pediatric multiple sclerosis.

Margoni MargoniPaolo PreziosaElisabetta PaganiLoredana StorelliMor GueyeLucia MoiolaMassimo Filippi Maria Assunta Rocca

Published in: Annals of clinical and translational neurology (2024)

The evaluation of white matter lesions (WMLs) showing the central vein sign (CVS) and paramagnetic rim lesions (PRLs) has been suggested to enhance the diagnostic work-up of adult multiple sclerosis (MS). We aimed to evaluate the fulfillment of different CVS criteria and the added value of PRLs in 22 pediatric MS patients. Eleven patients (50%) fulfilled the 40%-rule threshold. Nineteen (86%) patients had ≥3 CVS+ WMLs or ≥1 PRL, whereas 17 (77%) had ≥6 CVS+ WMLs or ≥1 PRL. A simplified CVS-based approach, with the combined evaluation of ≥1 PRL in patients with ≥6 CVS+ WMLs, may improve MS diagnosis in pediatric patients.

Keyphrases

multiple sclerosis
end stage renal disease
white matter
ejection fraction
newly diagnosed
mass spectrometry
ms ms
young adults
patient reported