A Novel Putative Role of TNK1 in Atherosclerotic Inflammation Implicating the Tyk2/STAT1 Pathway.

Mei-Hua BaoQiao-Li LvHai-Gang LiYi-Wen ZhangBao-Feng Xu Bin-Sheng He

Published in: Mediators of inflammation (2020)

TNK1 participated in the inflammation in atherosclerosis. shTNK1 suppressed the oxLDL-induced inflammation and lipid deposition in THP-1 cells. The mechanism might be related to the Tyk2/STAT signal pathway.

Keyphrases

oxidative stress
induced apoptosis
diabetic rats
cell proliferation
cell cycle arrest
high glucose
type diabetes
drug induced
signaling pathway
endoplasmic reticulum stress
stress induced