Pharmacogenomics of Coronary Artery Response to Intravenous Gamma Globulin in Kawasaki Disease.
Sadeep ShresthaHoward W WienerSabrina ChowdhuryHidemi KajimotoVinodh SrinivasasainagendraOlga A MamaevaUjval N BrahmbhattDolena LedeeYung LauLuz A PadillaJake Y ChenNagib DahdahHemant K TiwariMichael A PortmanPublished in: medRxiv : the preprint server for health sciences (2024)
This pharmacogenomics study provides insights into the pathogenesis of CAA/L in IVIG-treated KD patients. We have identified multiple novel SNPs associated with CAA/L and related genes with potential functional implications. The study shows that genomics can help define the cause of CAA/L to guide management and improve risk stratification of KD patients.
Keyphrases
- end stage renal disease
- coronary artery
- newly diagnosed
- ejection fraction
- chronic kidney disease
- peritoneal dialysis
- emergency department
- gene expression
- pulmonary artery
- pulmonary hypertension
- genome wide
- high dose
- patient reported outcomes
- single cell
- climate change
- clinical decision support
- electronic health record