ROS/TRPA1/CGRP signaling mediates cortical spreading depression.

Liwen JiangDongqing MaBlair D GrubbMinyan Wang

Published in: The journal of headache and pain (2019)

ROS/TRPA1/CGRP signaling plays a critical role in regulating cortical susceptibility to CSD. Inhibition ROS and deactivation of TRPA1 channels may have therapeutic benefits in preventing stress-triggered migraine via CGRP.

Keyphrases

cell death
dna damage
reactive oxygen species
depressive symptoms
sleep quality
physical activity