Vitamin B12 is neuroprotective in experimental pneumococcal meningitis through modulation of hippocampal DNA methylation.

Karina Barbosa de QueirozVanessa Cavalcante-SilvaFlávia Lombardi LopesGifone Aguiar RochaVânia D'AlmeidaRoney Santos Coimbra

Published in: Journal of neuroinflammation (2020)

Hcy is likely to play a central role in hippocampal damage in the infant rat model of BM, and B12 shows an anti-inflammatory and neuroprotective action through methyl-dependent epigenetic mechanisms.

Keyphrases

cerebral ischemia
dna methylation
subarachnoid hemorrhage
anti inflammatory
blood brain barrier
brain injury
gene expression
genome wide
oxidative stress
cerebrospinal fluid
copy number