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Quantifying the effects of absorbed dose from radioembolisation on healthy liver function with [99mTc]TcMebrofenin.

Kathy P WillowsonGeoffrey P SchembriElizabeth J BernardDavid Lh ChanDale L Bailey
Published in: European journal of nuclear medicine and molecular imaging (2020)
Given the significant negative relationship between baseline and change in global liver uptake rate, baseline HBS studies should not be used alone to disqualify patients considered for RE. In terms of treatment planning and evaluation, D70 may be the most appropriate metric of dose, with values greater than 15 Gy indicative of a likely drop in global liver function. The evidence of increasing functional burden in spared liver volumes suggests that patients at risk of complications could benefit from a lobar approach to treatment.
Keyphrases
  • end stage renal disease
  • ejection fraction
  • chronic kidney disease
  • peritoneal dialysis
  • spinal cord injury
  • spinal cord
  • combination therapy
  • replacement therapy
  • patient reported