Efficacy of sertraline against Trypanosoma cruzi: an in vitro and in silico study.
Daiane Dias FerreiraJuliana Tonini MesquitaThais Alves da Costa SilvaMaiara Maria RomanelliDenise da Gama Jaen BatistaCristiane França da SilvaAline Nefertiti Silva da GamaBruno Junior NevesCleber Camilo Melo-FilhoMaria de Nazare Correia SoeiroCarolina Horta AndradeAndre Gustavo TemponePublished in: The journal of venomous animals and toxins including tropical diseases (2018)
The present study demonstrated that sertraline had a lethal effect on different forms and strains of T. cruzi, by affecting the bioenergetic metabolism of the parasite. These findings provide a starting point for future experimental assays and may contribute to the development of new compounds.