Identification of quinoline derivatives as growth inhibitors of MDR pathogen <i>Klebsiella pneumoniae</i>.
Farzeen GhazalSaba FarooqAtia-Tul WahabRukesh MaharjanHumaira ZafarHina SiddiquiSara ShafiMouhamat Iqbal ChoudharyPublished in: Future microbiology (2022)
<b>Aims:</b> This study was aimed to identify compounds with significant inhibitory potential against multidrug-resistant (MDR), multidrug-sensitive and clinical isolates of <i>Klebsiella pneumoniae</i>. <b>Materials & methods:</b> Antibacterial activity of the nitroquinoline derivatives was assessed by micro-plate Alamar Blue assay. <b>Results:</b> Nitroquinoline derivatives <b>9</b>, <b>11</b> and <b>14</b> showed inhibitory activity against MDR <i>K. pneumoniae</i>. Docking studies of these compounds with topoisomerase IV of <i>K. pneumonia</i> indicated the interactions of these compounds at the active site residues of enzyme near to cofactor (Mg<sup>+2</sup>). Furthermore, compound <b>11</b> was identified as a reactive oxygen species (ROS) inducer. None of the compounds showed hemolytic effect. <b>Conclusion:</b> This study was designed to identify compounds active against MDR <i>K. pneumoniae</i> which causes infections, such as pneumonia and urinary tract infections.
Keyphrases
- multidrug resistant
- klebsiella pneumoniae
- drug resistant
- gram negative
- acinetobacter baumannii
- reactive oxygen species
- urinary tract infection
- escherichia coli
- cell death
- climate change
- dna damage
- risk assessment
- molecular dynamics simulations
- molecular docking
- respiratory failure
- candida albicans
- human health
- bioinformatics analysis