Patients with abdominal aortic aneurysms have reduced levels of microRNA 122-5p in circulating exosomes.
Jose L LopezJoel L RamirezTuan Anh PhuPhat DuongLaura BouchareychasChristina R KuhrauPei-Yu LinWalter L EckalbarAndrea J BarczakJoshua D RudolphLenka MaliskovaMichael S ConteShant M VartanianRobert L RaffaiAdam Z OskowitzPublished in: PloS one (2023)
Plasma exosomes from AAA patients have significantly reduced levels of miRNA-122-5p compared to controls. This is a novel exosome-associated miRNA that warrants further investigation to determine its use as a diagnostic biomarker and potential implications in AAA pathogenesis.