Patients with abdominal aortic aneurysms have reduced levels of microRNA 122-5p in circulating exosomes.

Jose L LopezJoel L RamirezTuan Anh PhuPhat DuongLaura BouchareychasChristina R KuhrauPei-Yu LinWalter L EckalbarAndrea J BarczakJoshua D RudolphLenka MaliskovaMichael S ConteShant M VartanianRobert L RaffaiAdam Z Oskowitz

Published in: PloS one (2023)

Plasma exosomes from AAA patients have significantly reduced levels of miRNA-122-5p compared to controls. This is a novel exosome-associated miRNA that warrants further investigation to determine its use as a diagnostic biomarker and potential implications in AAA pathogenesis.

Keyphrases

end stage renal disease
abdominal aortic
mesenchymal stem cells
stem cells
ejection fraction
newly diagnosed
chronic kidney disease
peritoneal dialysis
prognostic factors
risk assessment
patient reported