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Patients with abdominal aortic aneurysms have reduced levels of microRNA 122-5p in circulating exosomes.

Jose L LopezJoel L RamirezTuan Anh PhuPhat DuongLaura BouchareychasChristina R KuhrauPei-Yu LinWalter L EckalbarAndrea J BarczakJoshua D RudolphLenka MaliskovaMichael S ConteShant M VartanianRobert L RaffaiAdam Z Oskowitz
Published in: PloS one (2023)
Plasma exosomes from AAA patients have significantly reduced levels of miRNA-122-5p compared to controls. This is a novel exosome-associated miRNA that warrants further investigation to determine its use as a diagnostic biomarker and potential implications in AAA pathogenesis.
Keyphrases
  • end stage renal disease
  • abdominal aortic
  • mesenchymal stem cells
  • stem cells
  • ejection fraction
  • newly diagnosed
  • chronic kidney disease
  • peritoneal dialysis
  • prognostic factors
  • risk assessment
  • patient reported