Palladium-Catalyzed Tandem Reaction of Three Aryl Iodides Involving Triple C-H Activation.
Xiai LuoYankun XuGenhua XiaoWenjuan LiuCheng QianGuobo DengJianxin SongYun LiangChunming YangPublished in: Organic letters (2018)
A novel palladium-catalyzed tandem reaction of N-(2-iodoaryl)acrylamides with two aryl iodides for the synthesis of spirooxindole has been achieved. The reaction underwent the process of triple C-H activation and four C-C bond formations based on the double trapping of transient spirocyclic palladacycles which are obtained through remote C-H activation.