Behavioral and biological divergence in monozygotic twin pairs discordant for autism phenotypes: A systematic review.

Lynnea MyersPei-Yin PanKarl Lundin RemnéliusJanina NeufeldPeter B MarschikUlf JonssonSven Bölte

Published in: JCPP advances (2021)

Our results suggest that NSE in ASD could be associated with heterogeneous postzygotic genetic mechanisms and manifest as a range of biological and behavioral phenotypes. Extant findings were limited by relatively few studies, small sample sizes, and methodological diversity. More research is needed on co-occurring biological and behavioral phenotypes using a consistent format for designing, analyzing, and reporting MZ ASD discordant twin studies in order to further examine the role of NSE in the etiology of ASD.

Keyphrases

autism spectrum disorder
intellectual disability
attention deficit hyperactivity disorder
case control
gene expression
emergency department
copy number
dna methylation
working memory
drug induced