Folate receptor-targeted positron emission tomography of experimental autoimmune encephalomyelitis in rats.

Petri EloXiang-Guo LiHeidi LiljenbäckSemi HelinJarmo TeuhoKalle KoskensaloVirva SaunavaaraPäivi MarjamäkiVesa OikonenJenni VirtaQingshou ChenPhilip S LowJuhani KnuutiSirpa JalkanenLaura AirasAnne Roivainen

Published in: Journal of neuroinflammation (2019)

Our EAE results imply that FR-β may be a useful target for in vivo imaging of multiple sclerosis-related immunopathology. FR-β-targeted PET imaging with 18F-FOL may facilitate the monitoring of lesion development and complement the information obtained from TSPO imaging by bringing more specificity to the PET imaging armamentarium for neuroinflammation.

Keyphrases

pet imaging
positron emission tomography
multiple sclerosis
computed tomography
high resolution
cancer therapy
traumatic brain injury
cognitive impairment
lipopolysaccharide induced
drug delivery
white matter
inflammatory response
mass spectrometry
social media
brain injury
binding protein
drug induced