Synthesis, antioxidant and antitumoral activities of 5'-arylchalcogeno-3-aminothymidine (ACAT) derivatives.
Raquel Mello da RosaBruna Candia PiccoliFernanda D'Avila da SilvaLuciano DornellesJoão B T RochaMariana Souza SonegoKarine Rech BegniniTiago CollaresFabiana K SeixasOscar Endrigo Dorneles RodriguesPublished in: MedChemComm (2016)
This article presents the preparation and in vitro biological activities of new 5'-arylchalcogeno-3-aminothymidine derivatives as antioxidants (inhibition of lipid peroxidation, scavenging of the free radical 2,2-diphenylpicrylhydrazyl and demonstration of a thiol peroxidase-like activity) as well as antitumoral agents against bladder carcinoma 5637. The chalcogeno-aminothymidines presented prominent activity in the tests for both biological properties, showing a direct relation with the chalcogenium atom.