Differential Gene Expression Profile of Renin-Angiotensin System in the Left Atrium in Mitral Regurgitation Patients.
Wen-Hao LiuYen-Nan FangChia-Chen WuMien-Cheng ChenJen-Ping ChangYu-Sheng LinKuo-Li PanWan-Chun HoTzu-Hao ChangYao-Kuang HuangChih-Yuan FangChien-Jen ChenWei-Chieh LeePublished in: Disease markers (2018)
Expressions of genes in the renin-angiotensin system, especially CTSA, LNPEP, and MAS1, in the left atrium in MR patients significantly differed from expressions of these genes in aortic valve disease patients and normal controls. Notably, differences in expression were independent of circulating angiotensin II levels. The results of this study provide a rationale for pharmacological therapies or posttranslational regulation therapies targeting genes expressed differentially in the renin-angiotensin system to remedy structural remodeling associated with atrial enlargement and heart failure progression in patients with MR.
Keyphrases
- end stage renal disease
- heart failure
- gene expression
- angiotensin ii
- aortic valve
- newly diagnosed
- ejection fraction
- chronic kidney disease
- prognostic factors
- peritoneal dialysis
- magnetic resonance imaging
- genome wide
- atrial fibrillation
- dna methylation
- magnetic resonance
- computed tomography
- drug delivery
- coronary artery disease
- pulmonary arterial hypertension
- mitral valve
- pulmonary embolism
- vascular smooth muscle cells
- angiotensin converting enzyme
- contrast enhanced
- genome wide identification