Differences in Pharmacokinetic/Pharmacodynamic Parameters of Tedizolid Against VRE and MRSA.

Xiaoxi LiuSho TashiroYuki IgarashiWataru TakemuraNana KojimaTakumi MoritaMarina HayashiYuki EnokiKazuaki TaguchiKazuaki Matsumoto

Published in: Pharmaceutical research (2022)

Tedizolid showed bactericidal effects against VRE even in neutropenic mice unlike MRSA, which could be attributed to its longer PAE against VRE. Hence, we hypothesize that tedizolid treatment against VRE infections is promising for achieving therapeutic success in clinical.

Keyphrases

methicillin resistant staphylococcus aureus
staphylococcus aureus
high fat diet induced
type diabetes
metabolic syndrome
adipose tissue
replacement therapy
smoking cessation