Solanaceae glycoalkaloids: α-solanine and α-chaconine modify the cardioinhibitory activity of verapamil.
Szymon ChowańskiMagdalena Joanna WinkielMonika SzymczakPaweł MarciniakDominika MańczakKarolina Walkowiak-NowickaMarta Spochacz-SantoroSabino Aurelio BufoLaura ScranoZbigniew AdamskiPublished in: Pharmaceutical biology (2022)
The results show that attention to the composition of the daily diet during therapy with various drugs is particularly important. In subsequent studies, the nature of interaction between verapamil and SGAs on the molecular level should be checked, and whether this interaction decreases the efficiency of cardiovascular therapy with verapamil in humans.