High risk human papilloma viruses (HPVs) are present in benign prostate tissues before development of HPV associated prostate cancer.
Wendy K GlennChristopher C NganTimothy G AmosRichard J EdwardsJoshua SwiftLouise Lutze-MannFei ShangNoel J WhitakerJames S LawsonPublished in: Infectious agents and cancer (2017)
High risk HPVs are present in benign prostate tissues prior to the development of HPV positive prostate cancer. There is a significantly higher expression of HPV E7 oncoproteins in benign prostate tissues as compared to late prostate cancer that subsequently developed in the same patients. This observation suggests that HPV oncogenic activity is an early phenomenon in a majority of prostate oncogenesis. TCGA RNA-Seq data suggests that HPV is biologically active in some prostate tumour samples.
Keyphrases
- prostate cancer
- radical prostatectomy
- high grade
- rna seq
- gene expression
- single cell
- cervical cancer screening
- end stage renal disease
- endothelial cells
- ejection fraction
- benign prostatic hyperplasia
- prognostic factors
- transcription factor
- machine learning
- electronic health record
- patient reported outcomes
- big data
- data analysis
- genetic diversity