Mussel-inspired multifunctional hydrogel dressing with hemostasis, hypoglycemic, photothermal antibacterial properties on diabetic wounds.

To meticulously establish an efficient photothermal multifunctional hydrogel dressing is a prospective strategy for the treatment of diabetic chronic wounds. Herein, glucose oxidase (GO x ) was added to polydopamine/acrylamide (PDA/AM) hydrogels to reduce hyperglycemia to a normal level (3.9-6.1 mmol L -1 ) and enhance compressive properties (55 kPa) and adhesive properties (32.69 kPa), which are capable of hemostasis in the wound. Then, MnO 2 nanoparticles were encapsulated into a polydopamine/acrylamide (PDA/AM) hydrogel, endowing it with excellent antibacterial properties ( E. coli and S. aureus were 97.87% and 99.99%) under the irradiation of 808 nm NIR; meanwhile, the biofilm was eliminated completely. Besides, O 2 was generated (18 mg mL -1 ) by the decomposition of H 2 O 2 under the catalysis of MnO 2 , which could accelerate the formation of angiogenesis and promote the crawling and proliferation of cells. Furthermore, the diabetic wound in vivo treated with the PDA/AM/GO x /MnO 2 hydrogel had a less inflammatory response and faster healing speed, which was completely healed in 14 days. Therefore, the multifunctional hydrogels with the capability of high compressible, hemostasis, antibacterial, hyperglycemia manipulation, and O 2 generation, demonstrate promise in diabetic chronic wound dressing.