Disruption of transverse-tubular network reduces energy efficiency in cardiac muscle contraction.

Nicholas G Mellor Toan Pham Kenneth Tran Denis Scott Loiselle Marie-Louise Ward Andrew J Taberner David J Crossman June-Chiew Han

Published in: Acta physiologica (Oxford, England) (2020)

These results reveal the direct energetic consequences of disrupted t-tubular network, linking the energy disturbance and the t-tubular remodelling typically observed in heart failure.

Keyphrases

heart failure
high glucose
left ventricular
skeletal muscle
genome wide
endothelial cells
single cell
atrial fibrillation
gene expression
cardiac resynchronization therapy
resting state
acute heart failure
network analysis