Metal-(Acyclic Diaminocarbene) Complexes Demonstrate Nanomolar Antiproliferative Activity against Triple-Negative Breast Cancer.

Svetlana A Katkova Alexander S Bunev Rovshan E Gasanov Dmitry A Khochenkov Andrey V Kulsha Oleg A Ivashkevich Tatiyana V Serebryanskaya Mikhail A Kinzhalov

Published in: Chemistry (Weinheim an der Bergstrasse, Germany) (2024)

Hydrolytically stable Pd II and Pt II complexes supported by acyclic diaminocarbene ligands represent a novel class of structural organometallic anticancer agents exhibiting nanomolar antiproliferative activity in a panel of cancer cell lines (IC 50 0.07-0.81 μM) and up to 300-fold selectivity for cancer cells over normal primary fibroblasts. The lead drug candidate was 300 times more potent than cisplatin in vitro and showed higher efficacy in reducing the growth of aggressive MDA-MB-231 xenograft tumors in mice.

Keyphrases

papillary thyroid
type diabetes
squamous cell
high fat diet induced
anti inflammatory
skeletal muscle
cell death
insulin resistance