Variants of FOXO3 and RPA3 genes affecting IGF-1 levels alter the risk of development of primary osteoarthritis.

Iris C M PelsmaK M J A ClaessenP E SlagboomD van HeemstA M PereiraH M KroonY F M RamosM KloppenburgN R BiermaszI M Meulenbelt

Published in: European journal of endocrinology (2020)

Patients with primary OA had significantly higher IGF-1 levels compared to controls. Moreover, SNPs in the FOXO3 and RPA3 genes were associated with an altered risk of OA. Therefore, altered IGF-1 levels affect the development of OA, and are potentially the result of the pathophysiological OA process.

Keyphrases

knee osteoarthritis
pi k akt
genome wide
signaling pathway
transcription factor
binding protein
rheumatoid arthritis
copy number
bioinformatics analysis
dna methylation