Clinical Behavior and Molecular Landscape of Stage I p53-abnormal Low-Grade Endometrioid Endometrial Carcinomas.
Amy JamiesonLisa VermijClaire J H KramerJan J JobsenIna M Jürgenliemk-SchulzLudy C H W LutgensJan Willem M MensMarie A D HaverkortAnnerie SlotRemi A NoutJan OostingJoseph W CarlsonBrooke E HowittPhilip Pun-Ching IpSigurd F LaxW Glenn McCluggageNaveena SinghJessica Nell McAlpineCarien L CreutzbergNanda HorewegC Blake GilksTjalling BossePublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2023)
A subset of p53abn EC is morphologically low-grade EEC and exhibit genomic instability. Even for stage I disease, p53abn low-grade EEC are at substantial risk of disease recurrence. These findings highlight the clinical relevance of universal p53-testing, even in low-grade EEC, to identify women at increased risk of recurrence.