Enhancing Osteosarcoma Killing and CT Imaging Using Ultrahigh Drug Loading and NIR-Responsive Bismuth Sulfide@Mesoporous Silica Nanoparticles.
Yao LuLihua LiZefeng LinMei LiXiaoming HuYu ZhangMingying PengHong XiaGang HanPublished in: Advanced healthcare materials (2018)
Despite its 5-year event-free survival rate increasing to 60-65% due to surgery and chemotherapy, osteosarcoma (OS) remains one of the most threatening malignant human tumors, especially in young patients. Therefore, a new approach that combines early diagnosis with efficient tumor eradication and bioimaging is urgently needed. Here, a new type of mesoporous silica-coated bismuth sulfide nanoparticles (Bi2 S3 @MSN NPs) is developed. The well distributed mesoporous pores and large surface areas hold great promise for drug protection and encapsulation (doxorubicin (DOX), 99.85%). Moreover, the high photothermal efficiency of Bi2 S3 @MSNs (36.62%) offers great possibility for cancer synergistic treatment and highly near-infrared-triggered drug release (even at an ultralow power density of 0.3 W cm-2 ). After covalently conjugated to arginine-glycine-aspartic acid (RGD) peptide [c(RGDyC)], the NPs exhibit a high specificity for osteosarcoma and finally accumulate in the tumor cells (tenfold more than peritumoral tissues) for computed tomography (CT) imaging and tumor ablation. Importantly, the synergistic photothermal therapy-chemotherapy of the RGD-Bi2 S3 @MSN/DOX significantly ablates the highly malignant OS. It is further proved that the superior combined killing effect is achieved by activating the mitochondrial apoptosis pathway. Hence, the smart RGD-Bi2 S3 @MSN/DOX theranostic platform is a promising candidate for future applications in CT monitoring and synergistic treatment of malignant tumors.
Keyphrases
- computed tomography
- drug release
- cancer therapy
- photodynamic therapy
- dual energy
- drug delivery
- image quality
- contrast enhanced
- free survival
- positron emission tomography
- end stage renal disease
- minimally invasive
- newly diagnosed
- fluorescence imaging
- oxidative stress
- ejection fraction
- endothelial cells
- magnetic resonance imaging
- chronic kidney disease
- nitric oxide
- signaling pathway
- magnetic resonance
- oxide nanoparticles
- young adults
- locally advanced
- radiation therapy
- papillary thyroid
- peritoneal dialysis
- helicobacter pylori infection
- machine learning
- combination therapy
- lymph node metastasis
- acute coronary syndrome
- squamous cell carcinoma
- gene expression
- helicobacter pylori
- replacement therapy
- electronic health record
- deep learning
- cell cycle arrest
- percutaneous coronary intervention
- cell proliferation