Effect of MMP-2 gene silencing on radiation-induced DNA damage in human normal dermal fibroblasts and breast cancer cells.

Gugalavath ShailenderSeema KumariPatnala KiranmayiRama Rao Malla

Published in: Genes and environment : the official journal of the Japanese Environmental Mutagen Society (2019)

The results conclude that pMMP-2 has protected HDFs and sensitized the MCF-7 cells from IR induced DNA damage. This differential response might be due to IR induced MMP-2 distinctive ROS generation in HDFs and MCF-7 cells.

Keyphrases

dna damage
breast cancer cells
radiation induced
oxidative stress
high glucose
diabetic rats
dna repair
endothelial cells
induced apoptosis
radiation therapy
cell migration
induced pluripotent stem cells
wound healing