SUMO wrestling in the cellular dohyō: crosstalk between phosphorylation and SUMOylation of PKCδ regulates oxidative cell damage.

The novel PKCδ isoform has been shown to mediate a pro-apoptotic function in response to oxidative stressors. Siman Gao and colleagues performed an in-depth biochemical and molecular analysis of factors that regulate PKCδ function. They demonstrated convincingly that PKCδ is regulated by an interplay between SUMOylation and phosphorylation. They also showed that these events are critical for hydrogen peroxide induced apoptosis, thus identifying potentially novel mechanisms that may be harnessed for cell protection. Comment on: https://doi.org/10.1111/febs.16050.