High-Throughput Mechanistic Screening of Epigenetic Compounds for the Potential Treatment of Meningiomas.

Philip D TatmanTadeusz H WroblewskiAnthony R FringuelloSamuel R SchererWilliam B ForemanDenise M DamekKevin LilleheiA Samy YoussefRandy L JensenMichael W GranerD Ryan Ormond

Published in: Journal of clinical medicine (2021)

These findings strongly suggest an important role of HDACs in meningioma biology and as a targetable mechanism. Additional validation studies are necessary to confirm these promising findings, as well to identify an ideal HDAC inhibitor candidate to develop for clinical use.

Keyphrases

high throughput
gene expression
single cell
climate change
histone deacetylase
combination therapy
replacement therapy