Nintedanib modulates type III collagen turnover in viable precision-cut lung slices from bleomycin-treated rats and patients with pulmonary fibrosis.

Christina HesseValerie BenekeSebastian KonzokClaudia DiefenbachJannie Marie Bülow SandSarah Rank RønnowMorten Asser KarsdalDanny JonigkKatherina SewaldArmin BraunDiana Julie LeemingLutz Wollin

Published in: Respiratory research (2022)

This study demonstrated that nintedanib modulates neoepitope biomarkers of type III collagen turnover and indicated that C3M is a promising translational neoepitope biomarker of PF in terms of therapy assessment.

Keyphrases

type iii
pulmonary fibrosis
idiopathic pulmonary fibrosis
bone mineral density
interstitial lung disease
wound healing
tissue engineering
rheumatoid arthritis
systemic sclerosis
replacement therapy