Suppression of enteroendocrine cell glucagon-like peptide (GLP)-1 release by fat-induced small intestinal ketogenesis: a mechanism targeted by Roux-en-Y gastric bypass surgery but not by preoperative very-low-calorie diet.
Ville WalleniusErik EliasErik ElebringBauke HaismaAnna CasselbrantPierre LarraufieEmma SpakFrank ReimannCarel W le RouxNeil G DochertyFiona M GribbleLars FändriksPublished in: Gut (2019)
Intestinal ketogenesis is induced by high-fat diet and inhibited by RYGB surgery. In cell culture, ketone bodies inhibited GLP-1 release from EECs. Thus, we suggest that this may be a mechanism by which RYGB can remove the inhibitory effect of ketone bodies on EECs, thereby restituting the responsiveness of EECs resulting in increased meal-stimulated levels of GLP-1 after surgery.
Keyphrases
- roux en y gastric bypass
- weight loss
- high fat diet
- gastric bypass
- minimally invasive
- adipose tissue
- bariatric surgery
- coronary artery bypass
- obese patients
- insulin resistance
- surgical site infection
- single cell
- high glucose
- patients undergoing
- cell therapy
- physical activity
- skeletal muscle
- stem cells
- mesenchymal stem cells
- stress induced