The First Case of Granulicatella adiacens Identified from a Resected Heart Valve by Next Generation Sequencing (NGS) in Poland.
Anna PodgórskaMaria Kordybach-ProkopiukMaria Jaworska-WilczyńskaPiotr HoffmanKatarzyna BiernackaKrzysztof KuśmierskiRobert KuthanTomasz HryniewieckiAnna LutyńskaPublished in: Pathogens (Basel, Switzerland) (2022)
In this report, we describe the course and successful treatment of a case of complicated infective endocarditis (IE). A patient presented with a high-grade, irregular fever with chills lasting at least 2 months along with dyspnoea, chest pain, fatigue, weight loss, and night sweats during the previous 3 months. As well as cardiac congenital disorders, he was found to have Granulicatella adiacens infective aortic valve endocarditis, presumably transmitted from the oral cavity niche. Validated metagenomic 16S rDNA next generation sequencing was used to perform taxonomic identification, allowing for specific adequate antibiotic therapy instead of empiric therapy. This paper highlights the critical role of rapid taxonomic identification of nutritionally variant streptococci and the benefit of proper IE treatment in avoiding relapses or fatal complications.
Keyphrases
- aortic valve
- transcatheter aortic valve replacement
- high grade
- aortic stenosis
- weight loss
- transcatheter aortic valve implantation
- aortic valve replacement
- copy number
- heart failure
- bariatric surgery
- sleep quality
- risk factors
- circulating tumor
- lymph node
- left ventricular
- mitral valve
- gene expression
- physical activity
- depressive symptoms
- mesenchymal stem cells
- antibiotic resistance genes
- insulin resistance
- obese patients