Quality and potency profile of eight recombinant isoallergens, largely mimicking total Bet v 1-specific IgE binding of birch pollen.
Christian Seutter von LoetzenAndreas ReuterJelena SpiricThomas SchulenborgIris BellinghausenElke VölkerLothar VogelPaul RöschDirk SchillerPublished in: Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology (2019)
Bet v 1 variants previously classified as hypoallergenic can exhibit similar functional IgE binding as Bet v 1.0101. Eight rBet v 1 variants largely reproduce total Bet v 1-specific IgE binding of birch pollen extracts. Assay format-dependent variation in IgE-binding properties needs to be considered in the development of diagnostic or therapeutic products.